Recombinant Human Interleukin-4 protein (IL4)

1. IL-33 has a role in the pathogenesis of autoimmune hepatitis (AIH) and affects the expression of IL-4, IL-17A, and of hypergammaglobulinemia PMID: 30034292
2. Interleukin-4 induces a CD44high /CD49bhigh PC3 subpopulation with tumor-initiating characteristics. PMID: 29236307
3. Allelic polymorphism C590T of the gene IL-4 is the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children. PMID: 30480406
4. certain single nucleotide polymorphisms of IL4 gene could predispose individuals to recurrent aphthous stomatitis PMID: 29985726
5. Germline variants in IL4 gene are associated with prostate cancer. PMID: 29298992
6. The role of IL-4 in psoriasis. PMID: 28064550
7. By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13. PMID: 30104382
8. IL-4 polymorphisms might be associated with Kawasaki disease in an Iranian population. PMID: 28036156
9. association between root resorption and IL4 gene polymorphisms was observed. PMID: 28617966
10. these results demonstrated that variable number tandem repeat polymorphism in the IL-4 gene is associated with diabetic peripheral neuropathy in type 2 diabetes patients with coexisting cardiovascular disease PMID: 29182400
11. serum antibodies against HP-NAP represent a state of risk, which is further exacerbated in IL-4 -590 T carriers. PMID: 27677314
12. Polymorphisms at IL10 (-1082 G>A), IL4 (-589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases. PMID: 28750137
13. Defective sirtuin-1 was found to increase IL-4 expression through acetylation of GATA-3 in patients with severe asthma compared with healthy controls. PMID: 26627546
14. The results confirmed that the IL-4-590C/T polymorphism is correlated with the onset of RA and that carrying the T-allele can significantly increase the risk of rheumatoid arthritis in the Chinese Han population. PMID: 28975976
15. the IL-4-590 C>T polymorphism does not influence the development of head and neck cancer. PMID: 29185028
16. the present study suggests that IL-4 polymorphisms might play a role in susceptibility to inflammatory bowel disease and its major subtypes in the Iranian population PMID: 28872970
17. IL-4R plays an important role in regulating hepatocellular carcinoma (HCC)cell survival and metastasis, and regulates the activity of the JAK1/STAT6 and JNK/ERK1/2 signaling pathways. We therefore suggest that IL-4/IL-4R may be a new therapeutic target for HCC PMID: 28665449
18. IL-4 rs2227288 and IL-10 rs1800872 may contribute to an increased risk for virus-induced encephalitis. Through use of direct sequencing, we showed that genotypes of IL-4 rs2227288 and IL-10 rs1800872 may have particular host susceptibility to virus-induced encephalitis. IL-4 rs2227283 and IL-10 rs1800871 have no correlation in with risk of virus-induced encephalitis (both P>0.05) PMID: 28935853
19. IL-4 and IL-8 genetic polymorphisms determine susceptibility to chronic Aggregatibacter actinomycetemcomitans periodontitis. PMID: 28859277
20. The data indicate that USP4 interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease. PMID: 28791349
21. Results show that higher levels of black carbon (BC) were associated with lower methylation of IL4 promoter CpG-48 5 days later and increased FeNO. The magnitude of association between BC exposure and demethylation of IL4 CpG-48 measured 5 days later appeared to be greater among seroatopic children, especially those sensitized to cockroach allergens. PMID: 28588744
22. Association between the TT-genotype of IL-4 rs2070874 polymorphism and a severe phenotype of viral-induced wheeze further underlines the role IL-4 plays in the inflammation pathway leading to viral respiratory infections. PMID: 28950434
23. the effects of IL4 gene polymorphisms on cancer risk may vary by cancer type and by ethnicity. PMID: 28656227
24. these results showed that allergy responses further accelerated the IL-4-induced inhibition of tumor development through the activation of STAT6 pathways. PMID: 28587956
25. we identified a subgroup of CVID patients with defective IL-4 signaling in T cells, with severe clinical features of inflammation and autoimmunity. PMID: 28476239
26. The difference between allelic and genotypic frequencies of interleukin-4 (-590C/T) between patients and controls was not significant (p = 0.46). PMID: 29372577
27. Data suggest that miRNA-340/429, which targeted IL-4, might be a potential approach for cancer treatment. PMID: 27895317
28. this paper shows that expression of non-secreted IL-4 is associated with histone deacetylase inhibitor-induced cell death, histone acetylation and c-Jun regulation in gamma/delta T-cells PMID: 27556516
29. Human CCL1 gene is selectively targeted by AhR in M(IL-4) macrophage. IL-4-induced epigenetic modification potentiates AhR-mediated CCL1 expression. PMID: 27888289
30. Liver IL-4 mRNA is downregulated in patients with pancreatic cancer and cachexia. PMID: 27897439
31. Low IL4 expression is associated with melanoma. PMID: 26993600
32. In this review, we discuss the molecular mechanisms driving IL-4 production in Th2 and Tfh cells. PMID: 27072069
33. In this review, we discuss the structural details of IL-4 and IL-4Ralpha subunit and the structural similarities between IL-4 and IL-13. We also describe detailed chemistry of type-I and type-II receptor complexes and their signaling pathways. Furthermore, we elaborate the strength of type-II hetero dimer signals in response to IL-4 and IL-13. PMID: 27165851
34. IL-4 and IL-17 modulate the functional activity of phagocytes in the maternal blood, cord blood, and colostrum of diabetic mother. PMID: 29135055
35. There was no significant difference in serum level of IL-4 between children with MPP (Mycoplasma pneumoniae pneumonia)and those with non-MPP. Among children with MPP, we found similar level of IL-4 regardless of the personal and family history of allergy and asthma or the presence of wheezing. PMID: 28057814
36. The functional promoter polymorphisms IL4-590C/T and IL6-174G/C, which affect the IL-4 and IL-6 levels in north Indian subjects, were associated with kidney dysfunction and CKD PMID: 27996163
37. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. PMID: 29262348
38. CGRP and IL-4 positively regulated APN/CD13 expression and activity in psoriatic fibroblasts. PMID: 28387421
39. Results from these two large randomized aerobic exercise intervention trials suggest that aerobic exercise does not alter IL-10 or IL-4 in a manner consistent with chronic disease and cancer prevention. PMID: 27485297
40. IL-4 signaling up-regulates the IL-25 axis in human monocytic cells, and IL-25 may provide autocrine signals in monocytes and macrophages to sustain IL-17Rb expression and predispose to alternative activation. PMID: 28421819
41. IL4 VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity. PMID: 28293435
42. Our results showed the role of IL4 in promoting breast cancer aggressiveness PMID: 28400477
43. These data identified the IL-4/CXCL12 loop as a previously unrecognized pathway involved in lymphoid stroma polarization and as a potential therapeutic target in Follicular lymphoma patients. PMID: 28202459
44. IL-4 genetic variations associated with susceptibility to or protection against chronic periodontitis are directly associated with influencing the response of immune cells to periodontopathogens PMID: 28114408
45. in HIV/AIDS patients under antiretroviral therapy, IL-4 and IL-10 levels were significantly lower in lipodystrophy vs. non-lipodystrophy PMID: 28189545
46. autologous CD4(+) T cells that are exposed to EVs from CD40/IL-4-stimulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with tumor cells. PMID: 27118451
47. IL-4 substantially restores CD79b protein expression, sIgM expression, and BCR signaling. PMID: 27226435
48. Tandem repeat polymorphisms of IL4 is associated with the severity of chronic periodontitis. PMID: 28053321
49. Keratinocyte gene expression is critically shaped by IL-4, altering cell fate decisions, which are likely important for the clinical manifestations and pathology of allergic skin disease PMID: 27554818
50. Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 and interleukin-10 PMID: 28631559

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HGNC: 6014

OMIM: 147780

KEGG: hsa:3565

STRING: 9606.ENSP00000231449

UniGene: Hs.73917